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Some clinical trials utilizing beta-adrenergic antagonists have shown prophylactic benefit against postoperative atrial fibrillation8,eleven,13-17; other scientific tests, on the other hand, came to conflicting conclusions.38-forty A probable basis for this variance could possibly be that in certain studies, individuals randomly assigned to placebo were dealt with with beta-adrenergic blockers until eventually the time of surgical treatment.forty one Thus, these clients may have experienced beta-blocker withdrawal, that is associated with an increase in the incidence of postoperative atrial fibrillation.eleven,forty two,43 A 2nd disadvantage with the scientific studies investigating prophylactic beta-blocker therapy may be the exclusion conditions. In most trials, the elements calling for exclusion have included a historical past of asthma, Long-term obstructive lung disease, or diabetes mellitus demanding professional medical therapy; the presence of the remaining ventricular aneurysm; The reality that concomitant or primary valvular surgery was to be performed; and the presence of congestive coronary heart failure.

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